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Pemanfaatan tumbuhan obat harus tetap memperhatikan dosis karena bila melebihi akan menimbulkan efek toksik. telah lama digunakan sebagai obat tradisional. Utilization of medicinal plant as traditional medicine should always be consider to doses.ĪBSTRAK Tumbuhan Hyptis capitata Jacq. There was no significant difference between P1 and P2 treatments on rats liver damage. The lowest liver damage was in rats given K+ treatment.

The liver damage in rats was not statistically significant difference between P3 and K-treatments.

The result showed that rats given P3 treatment had the highest liver damage. Both macroscopic and microscopic of liver damage were assessed. Zero point five ml ethanol 96% was given daily (K-) and without given anything (K+) was also conducted as a control. leave extract was given orally to rats every 24 hours during 14 days. The aim of this study was to measure the liver damage in rats caused by H. Utilization of medicinal plant must always consider to given dose because of toxic effect when too much medicine is taken. plant has been using for traditional medicine. The results showed that SENO at dosage up to 5000 mg/kg in acute study was safe, and NOAEL (no-observed-adverse-effect levels) in the sub-acute, was up to 1000 mg/kg. No significant changes in general behavior were reported regarding the acute study, while the sub-acute study demonstrated no toxicity of the hematopoietic and biochemical systems. On the 29th day, rats were fasted, anesthetized, euthanized, then their blood used for hematological and biochemical evaluation. In the sub-acute study, female and male rats, age 10 weeks, were supplemented at doses of 250, 5 mg/kg for 28 days. In the acute toxicity study, dose estimated was LD50 in the range of 2000-5000 mg/kg, signs of mortality and toxicity on female rats were observed for 14 days, after single doses of 20 mg/kg. High-Performance Liquid Chromatography (HPLC) analyzed the chemical composition, from aerial parts of watercress. The purpose of the study was to investigate the safety of the standardized extract of Nasturtium officinale (SENO) with phenylethyl glucosinolate 5.0 mg/ml-1, using acute and sub-acute oral dosage in Wistar rats. The leaves of this plant, which contain glucosinolate, are used for its diuretic and hypoglycemic effects. Nasturtium officinale (watercress) is a perennial dicotyledonous plant, rich in vitamins, minerals and chemical compounds.

Keywords: acute toxicity, Nasturtium officinale R. LD50 test demonstrated the practical test material is not toxic because no test animals died. Histopathological results at the highest doses showed necrosis and hydropic degeneration of the liver, serosis the kidneys, and the heart inflammation with myofibril irregular heart.

LD50 test is determined by the number of deaths in the test group during the 14 days of treatment in the form of one administration of the test materials. Group 1 as the control group were given Na – CMC 0,5 % b/v and groups 2-8 were given ethanol extract of watercress herb with a doses of 0,5 5 20 mg/kg bw. Test animals used were 40 male mice and 40 female mice were divided into 8 groups. This study aims to observe the histopathology liver, kidney, heart mice and to determine the LD50. Watercress has efficacy in the treatment of a hypo-allergenic, anti-diabetic, antioxidant, anticancer, and treatment of tuberculosis.The purpose of this research was to determine the potential for acute toxicity of ethanolic extract of watercress. Br.) is an annual plant of the Brasicaceae family.

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